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Actual physical dependence on the prescribed medication doesn't signify addiction. Actual physical dependence involves the event of a withdrawal syndrome when There may be sudden reduction or cessation in drug use or if an opiate antagonist is administered. Bodily dependence is usually detected just after a couple of days of opioid therapy. However

Early symptoms pursuing a probably hepatotoxic overdose may well consist of: nausea, vomiting, diaphoresis, and general malaise. Medical and laboratory proof of hepatic toxicity will not be obvious until eventually 48 to seventy two several hours post-ingestion.When this medication is utilized for years, it may well not do the job as well. Speak wi